Fig. 1.

Food intake (A), net cumulative food intake (B), body weight (C), plasma leptin (D), and insulin concentrations (E) in wild-type (WT; n = 5) and neuropeptide Y (NPY)^−/− (n = 7) mice in response to intravenous infusion of the melanocortin 3/4 receptor (MC3/4R) agonist melanotan II (MTII) for 7 days in WT and NPY^−/− mice. *P < 0.05 compared with control period, 2-way ANOVA with Tukey’s post hoc multiple comparison test; #P < 0.05 NPY^−/− mice compared with WT mice, 1-way ANOVA with repeated measures.