Food intake (A), body weight (B), and blood glucose (C) responses to diabetes and diabetes plus intravenous infusion of the MC3/4R agonist MTII for 7 days in WT (n = 5) and NPY−/− (n = 8) mice. Blood samples for glucose were obtained on day 5 of the control period, day 7 of diabetes, and on day 14 of diabetes plus day 7 of MC3/4R agonist infusion. *P < 0.05 compared with control period; #P < 0.05 NPY−/− mice compared with WT mice, 1-way ANOVA with repeated measures.