Skip to main content
. Author manuscript; available in PMC: 2018 May 24.
Published in final edited form as: Curr Opin Toxicol. 2017 Apr;3:40–47. doi: 10.1016/j.cotox.2017.04.004

Figure 1. Antiandrogen AOP network (and Graphical Abstract).

Figure 1

Adverse outcome pathway network for disrupted androgen- and insulin-like hormone 3 (INSL3)-dependent reproductive development in male rats. The first column of the AOP network identifies three classes of chemicals known to disrupt the androgen-signaling pathways via three different mechanisms of action. Different colored arrows indicate the pathway through which each set of chemicals exerts its affects: …blue arrows, androgen receptor (AR antagonists); green arrows, dual mechanism of action chemicals (AR antagonists and steroid enzyme inhibitors); and red arrows, phthalates (molecular initiating event unknown, but known to inhibit fetal testosterone (T) production). [7] Abbreviations: AR-androgen receptor; ARE- androgen receptor response element on target gene; mRNA- messenger ribonucleic acid.