Table 2.
Clinical trials of stem cells and orthopaedic applications registered at ClinicalTrials.gov (June 2015).
| Phase | Cell type | Status | Condition | Number enrolled | Institute | Completion | Access No. |
|---|---|---|---|---|---|---|---|
| Stem cells | Enrolling | Hip arthroplasty | 50 | University of Nebraska | April 2012 | NCT01366911 | |
| II | MSCs | Recruiting | Knee cartilage injuries | 16 | University of Jordan | June 2015 | NCT02118519 |
| II/III | Autologous MSCs | Unknown | Articular cartilage defects | 25 | Cairo University | December 2014 | NCT00891501 |
| II | Autologous MSCs | Not recruiting | Achilles tendinopathy | 10 | University College London | May 2016 | NCT02064062 |
| II | Allogeneic MSCs | Unknown | Osteoarthritis | 60 | Stempeutics Research Pvt Ltd | July 2014 | NCT01453738 |
| 0 | Allogeneic UCMSCs | Enrolling | Osteochondral lesion of talus | 28 | Samsung Medical Centre | August 2015 | NCT02338375 |
| I/II | MSCs | Completed | Meniscectomy | 55 | Mesoblast | April 2008 | NCT00225095 |
| I | MSCs | Unknown | Bone healing | 5 | University of Indonesia | December 2014 | NCT01725698 |
| II | MSCs | Recruiting | Hip avascular necrosis | 30 | Universidad Autónoma de Madrid | February 2017 | NCT02065167 |
| I/II | Autologous MSCs | Unknown | Chondral knee defects | 30 | Fundación para la Investigación Biomédica del Hospital Universitario La Paz | June 2012 | NCT01399749 |
| II | Allogeneic MSCs | Recruiting | Tibial closed diaphyseal fractures | 40 | Royan Institute | December 2015 | NCT02140528 |
| I/II | MSCs | Active, not recruiting | Knee osteoarthritis | 30 | University of Navarra | November 2014 | NCT02123368 |
| Enrolling | Posterolateral lumbar fusion | 60 | University of Utah | January 2016 | NCT01409954 | ||
| Autologous MSCs | Completed | Fracture non-union healing | 35 | Keele University | October 2011 | NCT02177565 | |
| I/II | MSCs/PRP | Recruiting | OA knee | 24 | Aditya K Aggarwal | June 2014 | NCT01985633 |
| I | Autologous MScs | Completed | Ankle joint osteoarthritis | 6 | Royan Institute | September 2011 | NCT01436058 |
| III | BMMSCs | Recruiting | Talar osteochondral lesion | 140 | Istituto Ortopedico Rizzoli | June 2015 | NCT02005861 |
| I | BMMSCs | Completed | Bone cyst | 6 | Royan Institute | October 2011 | NCT01207193 |
| II/III | MSCs | Withdrawn | Benign bone lesion | 0 | Emory University | March 2010 | NCT00851162 |
| Allogeneic MSCs | Active, not recruiting | Subtalar arthrodesis | 140 | AlloSource | February 2017 | NCT01413061 | |
| I/II | Autologous MSCs | Active, not recruiting | Enhance bone healing | 30 | Institut National de la Santé et de la Recherche Médicale, France | November 2015 | NCT01842477 |
| III | Autologous osteoblasts | Recruiting | Osteonecrosis | 130 | Bone Therapeutics S.A. | June 2017 | NCT01529008 |
| II/III | Autologous MSCs | Recruiting | Non-union treatments | 60 | Royan Institute | August 2017 | NCT02448849 |
| MSCs | Unknown | Osteoarthritis | 30 | University of Dresden | December 2010 | NCT01038596 | |
| II | MPCs | Active, not recruiting | Lumbar back pain | 100 | Mesoblast | July 2015 | NCT01290367 |
| I/II | Autologous MSCs | Recruiting | Knee OA | 12 | University of Toronto | February 2021 | NCT02351011 |
| III | Allogeneic MSCs | Recruiting | Chondrogenic discogenic lumbar back pain | 330 | Mesoblast | December 2017 | NCT02412735 |
| II | MSCs | Active, not recruiting | Lumbar interbody fusion | 24 | Mesoblast | July 2015 | NCT00996073 |