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. 2018 May 23;15:156. doi: 10.1186/s12974-018-1170-0

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — ACKR3 mRNA and protein expression in HBMEC after stimulation with LPS, TNF-α, or Ureaplasma spp. Levels of mRNA were assessed by qRT-PCR (a) and RNA sequencing (b). Flow cytometry was used to determine protein expression, events were gated for vital cells, with CD31 functioning as endothelial marker. For a stimulation period of 48 h, (c) shows the percentage of ACKR3- and CD31-positive cells, whereas dot plots of one representative experiment are given in (d). Data are presented as mean ± SD and significances are reported for comparisons vs. control and vs. broth (p values after logarithmic transformation, *p < 0.05, **p < 0.01, ***p < 0.001 vs. unstimulated control; °p < 0.05, °°p < 0.01, °°°p < 0.001, °°°°p < 0.0001 vs. broth)