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. 2018 May 23;15:39. doi: 10.1186/s12977-018-0422-5

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 10 — Schematic representation of the effect of Tat phosphorylation on HIV-1 transcription regulation. CDK2/cyclin E or DNA-PK phosphorylates Tat Ser-16 which facilitates binding to TAR RNA and reduces the interaction with CDK9/cyclin T1. PKR phosphorylates Tat Ser-46 which may affect Tat nuclear localization and prevents Tat binding to cyclin T1