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. 2018 Apr 30;14:1744806918777406. doi: 10.1177/1744806918777406

Figure 6.

Figure 6.

CBS inhibitor reversed upregulation of Nav1.7 expression and neuronal excitability. AOAA at 10 mg/kg was intraperitoneally injected for consecutive seven days. (a) Nav1.7 expression was reduced in T13-L2 DRGs when compared with normal saline (NS) group (n = 4 for each group, *p < 0.05 vs. NS, two-sample t test). (b) AOAA treatment hyperpolarized RP of colon-specific DRG neurons (n = 22 for each group, *p < 0.05 vs. NS, two-sample t test). (c) AOAA treatment significantly enhanced rheobase (n = 22 for each group, *p < 0.05 vs. NS, two-sample t test). (d) Examples of APs induced by 300-ms depolarizing current pulses injected through the patch pipette in colon-specific DRG neurons from NS- and AOAA-treated PMS rats. (e) AP numbers were not changed after injection of 10 mg/kg AOAA for seven days (n = 22 for each group, p > 0.05 vs. NS, two-sample t test).