Table 3.

Provisional Framework for Allogeneic Hematopoietic Cell Transplant Eligibility Criteria for AML Patients 60 Years and Older with Adequate Disease Control

Factor	Fit (All of the Below)	Vulnerable (Any of the Below)	Usually Exclude or Trial (Any of the Below)
Age, yr	<66	66–75	>75
Comorbidity	HCT-CI 0–2	HCT-CI 3–5	HCT-CI 6+ or severe organ dysfunction
KPS, %	90–100	70–80	<70
Function
IADL*	Normal	Any limitation	Limitations and HCT-CI 4+
Performance†	No impairment	Impaired	Severely limited
Cognitive	No impairment	Mild cognitive impairment, prior confusion	Moderate cognitive impairment
Other factors	Normal	Weight loss, single or limited caregiver, falls, albumin < 3.5 g/dL, limited motivation	Weight loss, single or limited caregiver, falls, albumin < 3.5 g/dL, limited motivation + others

KPS indicates Karnofsky performance score.

^*IADL used here omits the category of ability to do laundry.

^†Performance was measured by timed up and go, 4-m walk, and grip strength; 6-minute walk used for prehabilitation baseline.