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. 2018 May 17;9:528. doi: 10.3389/fphys.2018.00528

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Copyright © 2018 Jiki, Lecour and Nduhirabandi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Benefits of melatonin in cardiac pathologies. Melatonin, via its antioxidant, anti-inflammatory and immunomodulatory properties protects against ischemic heart disease as well as subsequent ischemic heart failure characterized by myocardial cell death (necrosis, apoptosis, autophagy) and cardiac dysfunction. Hypertension and pulmonary hypertension induce both cardiac fibrosis and pathological hypertrophy (cardiomyopathy) and subsequent heart failure. Melatonin reverses these effects as indicated with green arrows (↓: increase, ↑: reduce).