Figure 3.
Automated genotoxicity screening array: (A) 3D printed arrays without (left) and with (right) microwell chip with sample chambers containing dye solutions; (B) microwell-patterned pyrolytic graphite array. First row holds 1 μL water droplets retained by hydrophobic microwell boundaries. Microwells hold films of DNA, various metabolic enzymes, and RuPVP. A microprocessor controls 3 micropumps (one per channel) to analyze 3 samples per assay. Adapted from Kadimisetty, K.; Malla, S.; Rusling, J. F. Automated 3-D Printed Arrays to Evaluate Genotoxic Chemistry: E-Cigarettes and Water Samples. ACS Sensors 2017, 2, 670–678. Copyright American Chemical Soc., 2017.