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. 2018 May 24;8:8086. doi: 10.1038/s41598-018-26004-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Phylogenetic and comparative genomic analysis of the phage vB_EcoS_HSE2. (A) Phylogenetic analysis of phages that showed similarity with the phage vB_EcoS_HSE2. The phage genomes that showed similarity higher than 20% with the genome of phage vB_EcoS_HSE2 were collected and used for phylogenetic tree construction. (B) Core-genome analysis of phages from the same evolutionary branch with phage vB_EcoS_HSE2. The numbers of core genes for the 9 phages were indicated in the central circle, and the number of specific genes were also shown. (C) Dot plot analysis of phage vB_EcoS_HSE2 with phage K1ind1 and Jersery. The genes that were absent in phage K1ind1 genome are shown.