Fig. 1.

Distinct mutation patterns in Chinese NSCLC patients. a Loads of somatic mutations (substitutions and indels) or intra-chromosomal rearrangements (deletions, duplications, and inversions) identified in whole-genome sequencing data from Chinese NSCLC patients; b Mutation landscapes of significantly mutated genes (SMGs) in Chinese NSCLC patients. The frequencies shown in red indicate genes with significant differences between AD and SCC (FDR q < 0.05); c Significantly mutated genes (SMGs) with significantly different alteration frequencies in patients from the NJLCC and TCGA. Fisher’s exact test, ***P < 0.001; **P < 0.01; *P < 0.05; the gray star indicates a significantly different constitution of mutation types