Fig. 1.

Graphic summary of the exome analysis of relapsing APLs. a Number and type of somatic alterations identified at diagnosis (upper part) and acquired at relapse (lower part) for each patient. ND* indicates sample pairs with no available remission germline DNA, precluding determination of diagnostic alterations. b Somatic mutations (left) and copy-number alterations (right) observed at diagnosis (upper part) or relapse (lower part) at least twice in the study. Note the unexpected high prevalence and molecular variety of WT1 alterations