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. 2016 Jul 5;27(7):3724–3735. doi: 10.1093/cercor/bhw193

Figure 6.

Figure 6.

Systemic pretreatment with oxaloacetate reduces TNFα-mediated inhibition of LTP. (A) Time course graphs showing the effect of oxaloacetate on TNFα-mediated inhibition of LTP. The application of HFS (arrows) in animals pretreated i.v. (plus symbol) with vehicle and i.c.v. (asterisk) with TNFα (1.2 pmol) (Veh + TNFα) induced decremental LTP (P > 0.05 compared with pre-HFS baseline). In animals pretreated with oxaloacetate (35 mg/kg in 1 mL, i.v.) 40 min before TNFα (OXA + TNFα) the application of HFS 20 min later triggered a small but stable LTP (P < 0.05 compared with pre-HFS baseline). Insets show representative fEPSP traces at the times indicated. Calibration bars: vertical, 1 mV; horizontal, 10 ms. (B) Summary bar chart comparing the magnitude of synaptic potentiation at 3 h post-HFS between treatment groups. Values are the mean ± SEM fEPSP amplitude expressed as a percentage of the pre-HFS baseline. *P < 0.05.