Table S1.
Studies that have used TMS in the treatment of other addiction disorders
| Study | n | TMS device and parameters | Target area | Control group | Assessment | Results | |
|---|---|---|---|---|---|---|---|
| Nicotine | Johann et al103 | 11 | rTMS, 20 Hz, 90% MT | DlPfCx, left | Sham | Craving | Reduction in craving |
| Li et al104 | 16 | rTMS, 10 Hz, 100% MT | DlPfCx, left | Sham | Cue-induced craving | Reduction in craving | |
| Eichhammer et al105 | 14 | rTMS, 20 Hz, 90% MT | DlPfCx, left | Sham | Craving, smoking | No effect on craving, significant reduction in smoking | |
| Pripfl et al106 | 14 | rTMS, 10 Hz, 90% MT | DlPfCx, left | Sham | Cue-induced craving | Reduction in cue-induced craving | |
| Hayashi et al107 | 10 | rTMS, 1 Hz, 110% MT | DlPfCx, left | Sham | Cue-induced craving + fMRI | Reduction in cue-induced craving and reduction in fMRI signal in OfCx | |
| Rose et al108 | 15 | rTMS, 1 Hz, 10 Hz, 90% MT | SFG, MCx | Randomized open-label crossover | Cue-induced craving | Craving after smoking-cue presentations was elevated in the 10 Hz SFG and reduced after neutral-cue presentations; upon smoking, craving reduction in 10 Hz rTMS over SFG | |
| Amiaz et al60 | 48 | rTMS, 10 Hz,100% MT, | DlPfCx, left | Sham | Cue-induced craving, cigarette consumption | Reduction in cue-induced craving and cigarette consumption | |
| Wing et al109 | 15 | rTMS, 20 Hz, 90% MT | DlPfCx, left/right | Sham | Craving, smoking | Reduction in craving, no effect on smoking | |
| Prikryl et al110 | 35 | rTMS, 10 Hz, 110% MT | DlPfCx, left | Sham | Smoking | Reduction in smoking | |
| Dinur-Klein et al61 | 115 | H-coil,, 1/10 Hz, 110% MT | DlPfCx, bilateral, ICx | Sham | Cigarette consumption, craving | Reduction in craving and cigarette consumption after 10 Hz rTMS | |
| Trojak et al111 | 37 | rTMS, 1Hz, 120% MT | DlPfCx, right | Sham | Craving | No effect on craving | |
| Alcohol | Addolorato et al112 | 11 | Deep rTMS, 10 Hz, 100% MT | DlPfCx, bilateral | Sham | Intake, SPECT (DAT) | Decrease in alcohol intake and DAT availability |
| Mishra et al58 | 45 | rTMS, 10 Hz, 110% MT | DlPfCx, right | Sham | Craving | Reduction in craving | |
| Mishra et al113 | 20 | rTMS, 10 Hz, 110% MT | DlPfCx, right/left | Randomized double-blind | Craving | Reduction in craving after rTMS in both conditions | |
| Herremans et al114 | 36 | rTMS, 20 Hz, 110% MT | DlPfCx, right | Sham | Craving | No effect on craving | |
| Herremans et al115 | 29 | rTMS, 20 Hz, 110% MT | DlPfCx, right | Sham | Craving | No effect on craving | |
| Herremans et al116 | 26 | rTMS, 20 Hz, 110% MT | DlPfCx, right | Sham | Cue-induced craving | No effect on craving | |
| Höppner et al117 | 19 | rTMS, 20Hz, 90% MT | DlPfCx, left | Sham | Craving | No effect on craving | |
| Ceccanti et al57 | 18 | rTMS, 20Hz, 120% MT | MPfCx | Sham | Craving | Reduction in craving and drinking days | |
| del Felice et al118 | 17 | rTMS, 10Hz, 100% MT | DlPfCx, left | Sham | Craving, consumption | No effect on craving | |
| Heroin | Shen et al63 | 20 | rTMS, 10Hz, 100% MT | DlPfCx, left | Sham | Cue-induced craving | Reduction in cue-induced craving |
| Methamphetamine | Li et al62 | 10 | rTMS, 1Hz, 100% MT | DlPfCx, left | Sham | Craving | Increase in craving |
| Su et al119 | 30 | rTMS, 10 Hz, 80% MT | DlPfCx, left | Sham | Cue-induced craving | Reduction in cue-induced craving |
Abbreviations: rTMS, repetitive transcranial magnetic stimulation; MT, motor threshold; DlPfCx, dorsolateral prefrontal cortex; ICx, insular cortex; SFG, superior frontal gyrus; MCx, motor cortex; MPfCx, medial prefrontal cortex; fMRI, functional magnetic resonance imaging; SPECT, single-photon-emission computed tomography; OfCx, orbitofrontal cortex.