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. Author manuscript; available in PMC: 2018 May 24.
Published in final edited form as: Exp Neurol. 2017 Oct 19;299(Pt A):97–108. doi: 10.1016/j.expneurol.2017.10.014

Fig. 1.

Fig. 1

Increased permeability of blood-spinal cord-barrier (BSCB) in apoE deficient mice after SCI. BSCB permeability was evaluated by the extravasation of IgG using immunohistochemistry (A, B). Compared to wild type B6 mice (A), the extravasation of circulating IgG in the injury epicenter was significantly increased in apoE−/− mice at 3 days after SCI (B). Quantification of BSCB permeability using Evan Blue technique also showed that the amount of EB in the injured spinal cord was significantly increased in apoE−/− mice compared to wild type B6 mice at 1 day and 3 days after SCI. Scale bar = 500 µm in A, B. Data in C represent the mean ± SD, N = 4, stars represent p < 0.05.