Table 1.

Characteristics of Randomized Controlled Trials of D-Cycloserine Augmented Exposure-Based Cognitive-Behavioral Therapy (CBT)

Trial	N	Primary Diagnosis	Mean Age	% Male	% Comorbid Depressive Disorders	% ComorbidAnxiety Disorders	% on SRI Med	# of Therapy sessions	DCS Dose Timing in hours	# of DCS Doses	Analysis Type	Method Quality
Ressler et al.15	27	SP	46	41	0	0	NR	2	−3	2	ITT	26
Hofmann et al.16	32	SAD	34	67	15	33	33	5	−1	4	COMP	32
Storch et al.17	24	OCD	29	50	38	75	50	12	−4	12	COMP	31
Kushner et al.18	32	OCD	37	38	25	12.5	34.4	4	−2	4	ITT	31
Wilhelm et al.19	23	OCD	39	61	26	43	39	10	−1	10	ITT	31
Guastella et al.20	56	SAD	35	57	16	16	9	5	−1	4	ITT	36
Storch et al.21	30	OCD	12	63	10	27	30	10	−1	7	ITT	36
Otto at al.22	28	PD	37	50	17.9	28.6	54.5	5	−1	3	COMP	28
Litz et al.23	26	PTSD	32	100	30.8	11.5	7.7	6	−1	4	ITT	36
de Kleine et al.24	67	PTSD	38	19	54	42	25	8	−1	6	ITT	36
Nave et al.25	20	SP	37	40	5	0	10	1	−1	1	COMP	30
Farrell et al.26	17	OCD	13	41	12	59	76	9	−1	5	COMP	36
Rodebaugh et al.27	34	SAD	43	33	47	47	35	1	0	2	COMP	32
Hofmann et al.28	169	SAD	33	57	26.6	25.4	0	12	−1	5	ITT	38
Tart et al.29	29	SP	33	24	34	66	0	2	1	2	ITT	35
Mataix-Coles et al. 30	27	OCD	15	52	11	48	26	14	1	10	ITT	34
Scheeringa & Weems31	57	PTSD	12	44	61.4	59.7	10.5	12	−1	7	ITT	38
Rothbaum et al.32	106	PTSD	34	93	77.3	12.2	NR	6	−0.5	5	ITT	29
Difede et al.33	25	PTSD	46	76	64	NR	NR	12	−1.5	10	ITT	35
Andersson et al.34	128	OCD	35	42	9	25	24	12	−1	5	ITT	39

NOTE: NR= Not Reported, SP= Specific Phobia, PD= Panic Disorder, SAD= Social Anxiety Disorder, OCD= Obsessive-Compulsive Disorder, PTSD= Posttraumatic Stress Disorder, COMP=Completer Analysis, ITT=Intent-to-Treat Analysis