Figure 11. In vivo multiphoton imaging in V1 of CNP-eGFP mice reveals myelin injury post insertion.

In the hours following implantation, oligodendrocyte membranous protrusions (yellow ellipses) form in the cortical layer I myelinated axons near the electrode shank (blue). Cyan chevrons point to cell bodies. Note that some membranous protrusions emerge as soon as one hour post insertion (a,c,d), while some emerge hours later (b). Additionally, some protrusions recede over time (b,f). These are possible indicators of myelin damage or remodeling. Scalebars a–b: 100 µm; c–f: 12 µm