Table 4.
Worsening hematuria and risk of renal relapse
| Unadjusted sHR (95% CI) | P Value | Adjusted sHRa (95% CI) | P Value | |
|---|---|---|---|---|
| Any increase in hematuria level | ||||
| Since last visit | 1.32 (0.43 to 4.04) | 0.62 | 1.26 (0.42 to 3.77) | 0.68 |
| Over past 3 mo | 2.07 (0.79 to 5.42) | 0.14 | 2.13 (0.86 to 5.26) | 0.99 |
| Over past 6 mo | 3.72 (1.25 to 11.06) | 0.02 | 4.90 (1.81 to 13.27) | <0.01 |
| Over past 12 mo | 2.81 (0.91 to 8.68) | 0.07 | 3.91 (1.21 to 12.59) | 0.02 |
Risk of renal relapse (not including the hematuria component on the Birmingham Vasculitis Activity Score for Granulomatosis with Polyangiitis) is expressed as sHR and 95% CI. Among the 99 patients included in this analysis, 16 participants underwent renal relapse, and 27 patients had a competing event (21 participants had relapse without renal involvement and six patients developed ESRD). sHR, subdistribution hazard ratio; 95% CI, 95% confidence interval.
a
Adjusted for a decrease in hematuria over the same period, ANCA type (antiproteinase 3 versus antimyeloperoxidase), baseline pulmonary involvement, and baseline creatinine.