Table 3.

Associations between psychosocial factors and CKD outcomes in the Jackson Heart Study stratified at median age (55 years old)

Psychosocial Factorsa Stratified by Age	Prevalent CKD		Incident CKD		eGFR Decline
	OR (95% CI)b	P Value for Interaction	OR (95% CI)b	P Value for Interaction	β (95% CI)c	P Value for Interaction
Stressors		0.70		0.85		0.79
Age <55 yr	0.78 (0.62 to 0.98)		1.07 (0.77 to 1.49)		0.08 (−0.05 to 0.20)
Age ≥55 yr	0.74 (0.59 to 0.91)		1.03 (0.82 to 1.30)		0.10 (−0.04 to 0.25)
Moods		0.61		0.27		0.43
Age <55 yr	1.05 (0.84 to 1.31)		0.84 (0.59 to 1.19)		−0.01 (−0.14 to 0.11)
Age ≥55 yr	1.13 (0.93 to 1.36)		1.06 (0.84 to 1.33)		0.06 (−0.08 to 0.21)
Coping		0.28		0.47		0.36
Age <55 yr	1.15 (0.92 to 1.44)		0.81 (0.57 to 1.16)		−0.08 (−0.20 to 0.05)
Age ≥55 yr	0.97 (0.78 to 1.20)		0.95 (0.75 to 1.20)		0.02 (−0.14 to 0.17)

OR, odds ratio; 95% CI, 95% confidence interval.

^aPsychosocial factors are underlying constructs derived using principal component analysis separately for each outcome. Each factor features the following psychosocial variables that loaded heavily on it: (1) stressors: discrimination (daily, lifetime, and burden of lifetime) and stress across all CKD outcomes; (2) moods: hostility and anger across all CKD outcomes; and (3) coping: John Henryism, social status, and perceived social support across all CKD outcomes; it additionally included low spirituality for the prevalent and incident CKD outcomes and pessimism for eGFR decline outcome.

^bEstimates are from logistic regression (binary outcome).

^cEstimates are from linear regression (continuous outcome variable; milliliters per minute per 1.73 m² per year); all models were adjusted for age, sex, body mass index, family income, employment status, educational attainment, smoking status, diabetes, hypertension, and self-reported history of cardiovascular disease; eGFR decline model (linear regression) was additionally adjusted for baseline eGFR and albumin-to-creatinine ratio.