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. 2018 Feb 8;114(7):954–964. doi: 10.1093/cvr/cvy038

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© The Author(s) 2018. Published by Oxford University Press on behalf of the European Society of Cardiology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Increased maximal (F_max, A) and passive force (F_pas, B) were seen in DM + HC + HT as compared to Controls. Cardiomyocyte data were averaged for all measured cells and group averages are shown. Titin N2BA/N2B isoforms ratio was significantly decreased in DM + HC + HT animals (C). Typical examples of E and A waves in Control (D) and DM + HC + HT (E) animals and pressure–volume relationships (G) are presented. The early to late filling (E/A) ratio tended to be lower in the DM + HC + HT animals (F). End-diastolic elastance (slope of EDPVR, sEDPVR) was significantly increased (H) while a trend towards significance in the end-systolic elastance (slope of ESPVR, sESPVR) was recorded (I), *P < 0.05, ^#P = 0.10 DM + HC + HT vs. Control.