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. 2018 May 11;7(5):giy055. doi: 10.1093/gigascience/giy055

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© The Author(s) 2018. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1: — Experimental setup and fecal samples for establishment and assessment of the gene catalog of the gut microbiome in SD rats. Forty-nine SD rats were grouped into seven groups comprising a reference group (n = 7) fed a regular (low-fat) chow, a group of AIA rats treated with vehicle (n = 7), a group of AIA rats gavaged with L. casei (n = 7), a group of AIA rats gavaged with MTX (n = 7), a group of AIA rats gavaged with GJK (n = 7) or ZQFNT (n = 7),and a group of AIA rats fed a high-fat diet (D12492) (n = 7). Arthritis was induced by injection of CFA on day 0 after fecal sample collection; fecal samples were collected for five time points (TP) on day 0 (TP1), day 7 (TP2), day 14 (TP3), day 21 (TP4), and day 30 (TP5).