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. 2018 Mar 6;59(3):245–252. doi: 10.1093/jrr/rry005

Fig. 5.

Fig. 5.

Enhanced NK cell–mediated cancer cell lysis by combined treatment with bortezomib and ionizing radiation (IR). After treatment with 10 nM bortezomib with or without IR in IM-9 and RPMI-8226 cells, the myeloma cells (target cells) and NK-92 cells (effector cells) were cocultured for 4 h. The cytotoxicity of NK-92 cells compared with that of two kinds of myeloma cells was assayed (upper panel). Blank circles represents vehicle (DMSO)-treated cells. Gray-filled circles and black-filled circles represent bortezomib and combined treatment with IR and bortezomib, respectively. The blocking assay was performed after treating the myeloma cells with anti-NKG2D blocking antibody for half an hour. Black-filled circles represent combined treatment with IR and bortezomib, and blank circles represent NKG2D blocked cells, respectively. A single asterisk indicates P < 0.05.