Table 3.

Vision Change from Baseline, by Study Month

Study Month			Study Arm
			Sirolimus	Sham
2	Summary	N	22	22
		Median	−2.5	0.0
		Mean	−3.7	−5.4
		Stdev	9.2	16.5
	15-letter loss, N (%)		2 (9)	3 (14)
3	Summary	N	23	19
		Median	−3.0	−2.0
		Mean	−3.3	−7.6
		Stdev	9.8	17.9
	15-letter loss, N (%)		2 (9)	3 (16)
6	Summary	N	23	17
		Median	−3.0	−1.0
		Mean	−4.2	−10.2
		Stdev	12.8	20.4
	15-letter loss, N (%)		2 (9)	5 (29)
9	Summary	N	21	21
		Median	−3.0	−4.0
		Mean	−2.2	−9.2
		Stdev	8.9	17.4
	15-letter loss, N (%)		2 (10)	5 (24)
12	Summary	N	22	20
		Median	−3.5	−3.0
		Mean	−3.7	−7.3
		St dev	8.7	16.8
	15-letter loss, N (%)		1 (5)	4 (20)
18	Summary	N	16	11
		Median	−4.0	−3.0
		Mean	−4.5	−11.6
		St dev	8.8	22.4
	15-letter loss, N (%)		3 (19)	3 (27)
24	Summary	N	7	5
		Median	−4.0	−6.0
		Mean	−3.7	−10.6
		Stdev	8.6	16.2
	15-letter loss, N (%)		1 (14)	2 (40)

p-value for treatment effect (repeated measures logistic model): p=0.19