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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Best Pract Res Clin Haematol. 2017 Sep 22;30(4):333–335. doi: 10.1016/j.beha.2017.09.003

Table 2.

Summary of HLA Criteria for Donor Selection.

Unrelated Donor BM Unrelated Donor PBSC Haploidentical Donor Cord Blood Unit(s)

  1. Restrict to 1 HLA-A, B, C or DRB1

  2. Isolated DQB1 might be tolerable

  3. Avoid DQB1 + other mismatch

  1. Restrict to 1 HLA-A, B, C or DRB1

  2. Isolated DQB1 might be tolerable

  3. Avoid DQB1 + other mismatch

  4. RIC: 1 HLA mismatch is high risk

  1. NMA HCT with BM and post-HCT CY: overcomes HLA mismatching

  2. KIRs may promote anti-leukemic activity

  1. HLA-A, B low/DRB1 high resolution typing

  2. Consider HLA-C (↑ engraftment and ↓ NRM)

  3. Select better matched units with high cell dose

BM, bone marrow

PBSC, peripheral blood stem cells

RIC, reduced intensity conditioning

NMA, non-myeloablative conditioning

HCT, hematopoietic cell transplantation

CY, cyclophosphamide

KIR, killer immunoglobulin receptor

NRM, non-relapse mortality