Table 1.

The Gene Ontology annotation showing molecular function, biological process, and expression levels of 4 differentially expressed key proteins identified and quantified by Orbitrap/Q Exactive LC-MS/MS technique. Mean fold-change corresponds to the upregulation of protein expression when comparing TQ + LPS/IFNγ vs LPS/INFγ treatment groups. P-values (t-test) are listed in the table; (n = 3).

Protein				Mean fold change (TQ + LPS/IFNγ vs. LPS/IFNγ)	p-Value (T-test)	GO Annotation
UniProtKB accession number	Protein name	Protein ID	Molecular weight			Molecular function	Biological process
Q9CQM9	Glutaredoxin-3	GLRX3_MOUSE	38 kDa	21	0.00014	Protein disulfide oxidoreductase activity	Oxidation-reduction process
						Iron-sulfur cluster binding	Cell redox homeostasis
						Electron carrier activity	Response to stress
Q9CY64	Biliverdin reductase A	BIEA_MOUSE	34 kDa	15	< 0.00010	Biliverdin reductase activity	Heme catabolic process oxidation-reduction process
Q99J99	3-mercaptopyruvate sulfurtransferase	THTM_MOUSE	33 kDa	11	0.0022	3-Mercaptopyruvate sulfurtransferase activity	Hydrogen sulfide biosynthetic process
							Immune system process
							Response to toxic substance
Q8CGK3	Lon protease homolog, mitochondrial	LONM_MOUSE	106 kDa	8.1	0.00047	ATP & ADP binding	Aging
						ATPase activity	Cellular response to oxidative stress
						ATP-dependent peptidase activity	Response to hypoxia