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. Author manuscript; available in PMC: 2019 May 15.
Published in final edited form as: Bioorg Med Chem. 2018 Apr 4;26(9):2437–2451. doi: 10.1016/j.bmc.2018.04.010

Figure 5.

Figure 5

1H NMR of N4-desmethyl compound 3a and compound 3. In 3a, the 5-position hydrogens have a chemical shift 2.76 ppm. In compound 3, the 5-position hydrogens have a chemical shift 1.84 ppm. This is the result of the shielding effect of the aniline moiety. (400 MHz, solvent: DMSO-d6).