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. Author manuscript; available in PMC: 2018 May 24.
Published in final edited form as: J Control Release. 2018 Feb 26;276:1–16. doi: 10.1016/j.jconrel.2018.02.033

Fig. 1.

Fig. 1

Adjuvantation with 100 ng GM-CSF in intradermal H1N1 A/California/07/09 subunit vaccination improves antibody responses and enhances protection to lethal virus challenge. BALB/c mice (n = 4) were vaccinated ID with PBS, 1 μg HA, 3 μg HA, or 1 μg HA/100 ng GM-CSF. (A) Serum influenza-specific HAI titers are plotted at 8 weeks post-vaccination. Statistics for panel (A) were performed with Mann-Whitney test. Mice were challenged with 25xLD50 homologous virus 3 months post-vaccination and (B) survival and (C) body weight changes were recorded for 13 days. Percent body weight values are expressed as mean ± SEM. Statistics for panel (B) were performed with Mantel-Cox test.