Table 1.
Serum hormones, adipokines, and cytokines in MMTV-Wnt-1 mice on control or DIO diet regimens.
| Analyte | Control | DIO | p-value |
|---|---|---|---|
| Insulin (ng/mL) | 2.90 (0.53) | 6.30 (2.28) | 0.0004 |
| IGF-1 (ng/mL) | 59.9 (13.0) | 85.0 (35.2) | 0.06 |
| Leptin (ng/mL) | 5.29 (3.15) | 31.0 (20.3) | 0.0009 |
| Adiponectin (μg/mL) | 5.27 (0.75) | 4.84 (1.17) | 0.37 |
| Resistin (ng/mL) | 80.7 (41.2) | 216 (96.1) | 0.0007 |
| PAI-1 (ng/mL) | 1.78 (0.31) | 4.55 (4.58) | 0.09 |
| GIP (pg/mL) | 131 (49.1) | 279 (139) | 0.008 |
| GLP-1 (pg/mL) | 35.7 (13.4) | 50.7 (14.8) | 0.04 |
| Ghrelin (ng/mL) | 39.4 (2.3) | 39.9 (3.6) | 0.91 |
| Glucagon (pg/mL) | 154 (20.4) | 186 (25.2) | 0.33 |
| IL-1β (ng/mL) | 0.97 (0.05) | 1.05 (0.07) | 0.36 |
| IL-6 (pg/mL) | 157 (36.1) | 192 (49.6) | 0.09 |
| IL-10 (pg/mL) | 501 (33.2) | 578 (70.4) | 0.34 |
| IL-17A (ng/mL) | 1.21 (0.43) | 1.64 (0.46) | 0.05 |
| IFNγ (pg/mL) | 195 (25.0) | 241 (32.2) | 0.28 |
| MCP-1 (ng/mL) | 1.37 (0.08) | 1.38 (0.10) | 0.92 |
| TNFα (ng/mL) | 4.31 (1.25) | 5.81 (1.68) | 0.04 |
Multiplex immunoassay analyses performed on serum collected at euthanization (n=10/group). Standard deviations shown in parentheses. Abbreviations: IGF-1, insulin-like growth factor-1; PAI-1, plasminogen activator inhibitor-1; GIP, gastric inhibitory polypeptide; GLP-1, glucagon-like peptide-1; IL-1β, interleukin 1 beta; IL-6, interleukin 6; IL-10, interleukin 10; IL-17A, interleukin 17A; IFNγ, interferon gamma; MCP-1, macrophage chemoattractant protein 1; TNFα, tumor necrosis factor alpha.