Table 3.
Primary outcome of rate of rt-PA use for treatment of catheter malfunction
| Variable | Pre Period | Post Period |
|---|---|---|
| Total number of dialysis sessions with use of rt-PA for treatment of catheter malfunction | 1068 | 407 |
| Total catheter days | 58,050 | 40,430 |
| rt-PA use days per 1000 catheter days | 18.40 | 10.07 |
| Unadjusted incidence rate ratio for post versus pre rate of outcome (95% confidence interval) | 0.33 (0.24 to 0.44)a | |
| Adjusted incidence rate ratio for post versus pre rate of outcome (95% confidence interval) | 0.39 (0.30 to 0.52)a,b | |
rt-PA, recombinant tissue plasminogen activator.
a
From a three-level mixed effects negative binomial regression model, with enrollment nested within person and person nested within site. Person and site were treated as random effects.
b
Adjusted for age, sex, inclusion criteria, prior rate of catheter replacement, duration on dialysis, stroke, and history of deep venous thrombosis/pulmonary embolism.