TABLE 2.
Protein interactions involved in progression and pathogenicity of staphylococcal infection
| Organism | MSCRAMM(s) | Matrix/bridge protein(s) | Receptora | Functional response | Reference(s) |
|---|---|---|---|---|---|
| S. aureus | Collagen adhesion (CNA) | Collagen | NA | Colonization | 68, 201 |
| Bone sialoprotein (Bbp) | Fibrinogen | Bone sialoprotein | Unknown | 67, 202 | |
| Fibronectin binding proteins (FnBP) | Fibronectin | α5β1 | Internalization | 58–60 | |
| Staphylococcal protein A (SpA) | TNFR1 | Induction of bone loss (apoptosis) and bone destruction (osteoclastogenesis), inhibits mineralization | 51–54 | ||
| S. epidermidis | Serine-aspartate repeat-containing proteins (Sdr) | Fibrinogen, collagen | NA | Colonization | 13, 78, 79, 82 |
| Extracellular matrix binding protein (Embp) | Fibronectin | NA | Colonization | 83, 203, 204 | |
| Autolysin E (AtlE) | Vitronectin | NA | Colonization | 84 | |
| Autolysin adhesion protein (Aae) | Vitronectin | NA | Colonization | 85 | |
| GehD lipase | Collagen | NA | Colonization | 86, 205 |
a
NA, not available.