TABLE 5.

Commercially available bone-regenerative biomaterials, including collagen-based sponges and bone cement/beads, loaded with antimicrobials and used for treatment of osteomyelitis

Product	Company	Description	Indications
Collagen-based sponges
Collatamp G/EG	EUSA Pharma	Resorbable collagen implant impregnated with gentamicin	Prevent and treat surgical site infections through local antibiotic delivery
Genta-Coll	Resorba	Hemostyptic collagen sponge containing gentamicin	Hemostasis in wounds when there is high risk of infection (including in osteomyelitis)
Septocoll E	Biomet UK Ltd.	Resorbable equine collagen fleece containing 2 forms of gentamicin (gentamicin sulfate [rapid release] and gentamicin crobefate [protracted release])	Potentially contaminated/contaminated wounds; revision operations in septic surgery
Bone cement/beads
Septopal	Biomet UK Ltd.	PMMA chains loaded with gentamicin sulfate	Local drug delivery after surgical debridement
Stimulan	Biocomposites	Calcium sulfate (can mix with gentamicin, vancomycin, and tobramycin)	Complements dead space and infection management strategies (e.g., infected nonunions, osteomyelitis, and periprosthetic joint infection)
Palacos	Heraeus Medical	Bone cement (available with gentamicin)	Orthopedic replacement procedures