Figure 5.

DNA hypermethylation preferentially affects genes involved in suppression of kidney fibrosis and injury. (A) Pathway enrichment and (B) gene ontology enrichment of the genes associated with the 66 CpG islands that were hypermethylated after ischemia in both the longitudinal and preimplantation cohorts. (C) Log fold change in the expression of hypermethylated genes after versus before ischemia in the longitudinal cohort (n=2×13). Each boxplot represents one transcript: red indicates that expression is reduced after ischemia (median log fold change below one), and blue indicates that expression in increased after ischemia (median log fold change above one). BMP, bone morphogenetic protein. *P<0.05 by Wilcoxon test.