Table 1.

Top ten identified proteins with most significant fold changes in expression levels at 12 wk after induction of diabetes

Protein Name	Gene	Cont 6 wk	Cont 12 wk	STZ 6 wk	STZ 12 wk	STZ+Ins 12 wk	P Value	Adjusted Q Value
C4b-binding protein α chain	C4bpa	1.0	1.0	2.1	2.4	1.6	1.055e−07	1.787e−05
Vitamin K–dependent PS	Pros1	1.0	1.0	2.1	2.4	1.7	1.055e−07	8.933e−06
Brain acid soluble protein 1	Basp1	1.0	1.0	0.5	0.4	0.7	2.266e−07	1.278e−05
DnaJ homolog subfamily C member 2	Dnajc2	1.0	1.0	0.9	0.4	0.4	2.266e−07	9.586e−06
Solute carrier family 6, member 18	Slc6a18	1.0	1.0	0.5	0.4	0.6	2.266e−07	7.669e−06
Apo A-I	Apoa1	1.0	1.0	1.5	2.3	1.3	4.028e−07	1.136e−05
Complement C4	C4	1.0	1.0	2.1	2.2	1.7	1.53e−06	3.699e−05
C4b-binding protein β chain	C4bpb	1.0	1.0	2.3	1.9	1.0	7.856e−05	0.0017
Solute carrier family 43, member 3	Slc43a3	1.0	1.0	1.4	1.9	1.1	7.856e−05	0.0015
Alanyl aminopeptidase	Anpep	1.0	1.0	0.6	0.5	0.7	<0.001	0.0018

Protein expression levels at 6 and 12 wk of diabetes (STZ 6wk, STZ 12wk) are indicated as fold changes relative to age-matched nondiabetic vehicle-injected controls. We used a Z-test to test for significance of fold changes for individual proteins, and the Benjamini–Hochberg procedure to adjust for multiple hypothesis testing. Cont, control vehicle-injected; STZ, STZ-injected; Ins, treated with insulin.