Table 4.
Diagnostic accuracy of biomarkers for identifying patients with high bone turnover
| Biomarkers | AUC (95% CI) | Criterion | Sensitivity, % | Specificity, % | PPV, % | NPV, % |
|---|---|---|---|---|---|---|
| iPTH | 0.760 (0.60 to 0.88) | >327 pg/ml | 53 | 96 | 90 | 75 |
| Intact PINP | 0.765 (0.61 to 0.88) | >107 ng/ml | 53 | 92 | 82 | 74 |
| Total PINP | 0.725 (0.56 to 0.85) | >142 ng/ml | 75 | 68 | 60 | 81 |
| bALP | 0.750 (0.59 to 0.87) | >31 μg/L | 56 | 83 | 69 | 74 |
| tALP | 0.670 (0.51 to 0.81) | >102 IU/L | 65 | 73 | 61 | 76 |
| CTX | 0.762 (0.61 to 0.88) | >2.39 ng/ml | 53 | 96 | 90 | 75 |
| TRAP5b | 0.710 (0.55 to 0.84) | >4.6 U/L | 81 | 58 | 57 | 82 |
AUC, area under the receiver operating characteristic curve; 95% CI, 95% confidence interval; PPV, positive predictive value; NPV, negative predictive value; iPTH, intact parathyroid hormone; PINP, procollagen type 1 N-terminal propeptide; bALP, bone alkaline phosphatase; tALP, total alkaline phosphatase; CTX, collagen type 1 crosslinked C-telopeptide; TRAP5b, tartrate-resistant acid phosphatase 5b.