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. 2018 Feb 26;29(5):1411–1425. doi: 10.1681/ASN.2017111163

Figure 3.

Figure 3.

DCT-CA-SPAK does not alter expression of the ammonia signaling protein, NBCe1, or the ammonia transport proteins, NHE3, NKCC2 or Rhbg. Subfigure (A) shows effects on NBCe1 expression. Subfigure (B) shows effects on NHE3 expression. Left panel shows immunoblot analysis showing no significant difference in NHE3 expression and right panel shows immunolabel expression. Subfigure (C) shows NKCC2 expression by immunoblot analysis. Subfigure (D) shows Rhbg expression by immunoblot analysis. n=4 for each group in all subfigures. *PT segments. DCT-CA-SPAK, mice with early DCT-specific over-expression of constitutively active SPAK; WT, wild-type mice.