Table 1.
Plasma electrolytes in WT and DCT-CA-SPAK mice
| Plasma Electrolyte | WT (N) | DCT-CA-SPAK (N) | P Value |
|---|---|---|---|
| Na+ | 144.0±0.7 (12) | 145.8±0.5 (12) | NS |
| K+ | 3.85±0.03 (26) | 4.99±0.05 (16) | <0.001 |
| HCO3− | 23.7±0.2 (26) | 20.0±0.4 (16) | <0.001 |
| Cl− | 109.0±0.3 (22) | 115.3±0.5 (12) | <0.001 |
| Anion gap, mEq/L | 11.7±0.6 (22) | 10.6±0.8 (12) | NS |
Results are shown as mean±SEM. All results in millimoles per liter unless otherwise specified. WT, wild-type mice; DCT-CA-SPAK, mice with early DCT-specific over-expression of constitutively active SPAK.