Key resources table.
| Reagent type (species) or resource |
Designation | Source or reference | Identifiers | Additional information |
|---|---|---|---|---|
| gene (Rattus norvegicus) | GluN1-1a | U11418 | ||
| gene (Rattus norvegicus) | GluN1-1b | U08263 | ||
| gene (Rattus norvegicus) | GluN2A | D13211 | ||
| gene (Rattus norvegicus) | GluN2B | U11419 | ||
| gene (Rattus norvegicus) | GluN2C | M91563 | ||
| gene (Rattus norvegicus) | GluN2D | L31611 | ||
| cell line (Xenopus laevis) | stage VI oocytes | Ecocyte Biosciences (Austin, TX); Xenopus 1 (Dexter, MI) |
NA; #10004 | |
| cell line (Homo sapiens) | HEK293 | ATCC (Manassas, VA) | CRL-1573 | |
| commercial assay or kit | QuikChange kit | Agilent Technologies (Santa Clara, CA) |
200524 | |
| commercial assay or kit | mMessage mMachine SP6 or t7 |
Ambion/ThermoFisher Scientific (Waltham, MA) |
AM1340 or AM1344 | |
| chemical compound, drug | EU1794-4 | PMID: 26525866 | SMILES: CCOC(=O)C1 = C(NC(=O) CC2SC(=N)NC2 = O)SC2 = C1CCCC2 |
|
| chemical compound, drug | EU1794-2 | PMID: 26525866 | SMILES: CCOC(=O)C1 = C(NC(=O) CC2SC(=N)NC2 = O)SC2 = C1CCC(C)C2 |
|
| chemical compound, drug | EU1794-5 | this paper | SMILES: CC(C)OC(=O)C1 = C(NC(=O) CC2SC(=N)NC2 = O)SC2 = C1CCCC2 |
See sumplemental information |
| chemical compound, drug | EU1794-19 | this paper | SMILES: CC(C)OC(=O)C1 = C (NC(=O)CC2SC(=N)NC2 = O) SC2 = C1CCC(C)C2 |
See sumplemental information |
| chemical compound, drug | EU1794-25 | this paper | SMILES: CC1CCC2 = C(C1)SC(NC(=O) CC1SC(=N)NC1 = O)=C2C(=O) OC1 = CC = CC=C1 |
See sumplemental information |
| chemical compound, drug | EU1794-27 | this paper | SMILES: CC(C)(C)OC(=O)C1 = C (NC(=O)CC2SC(=N)NC2 = O) SC2 = C1CCCC2 |
See sumplemental information |
| chemical compound, drug | EU1794-29 | this paper | SMILES: CCCCOC(=O)C1 = C(NC(=O) CC2SC(=N)NC2 = O)SC2 = C1CCC(C)C2 |
See sumplemental information |
| chemical compound, drug | βCD | Acros Organics or ChemCenter |
2-(hydroxypropyl)-β-cyclodextrin (CAS# 128446-35-5) |
|
| chemical compound, drug | APV | Tocris (Minneapolis, MN) | (2)-amino-5-phosphonovaleric acid (CAS# 76326-31-3) |
|
| chemical compound, drug | 7-CKA | Tocris (Minneapolis, MN) | 7-chlorokynurenic acid (CAS# 18000-24-3) | |
| chemical compound, drug | MTSEA | TRC Canada (Toronto, ON) | Methanethiosulfonate ethylammonium (CAS# 16599-33-0) |
|
| chemical compound, drug | CIQ | Tocris (Minneapolis, MN) | CAS# 486427-17-2 | |
| chemical compound, drug | Ifenprodil | Tocris (Minneapolis, MN) | CAS# 23210-56-2 | |
| chemical compound, drug | PYD-106 | PMID: 25205677 | ||
| chemical compound, drug | TCN-201 | Tocris (Minneapolis, MN) | CAS# 852918-02-6 | |
| chemical compound, drug | GNE-6901 | PMID: 26875626; Genentech (San Francisco, CA) |
generously provided by Jesse Hanson and Genentech |
|
| chemical compound, drug | GNE-0723 | PMID: 26919761; Genentech (San Francisco, CA) |
generously provided by Jesse Hanson and Genentech |
|
| chemical compound, drug | DQP-1105 | Tocris (Minneapolis, MN) | CAS# 380560-89-4 | |
| chemical compound, drug | QNZ-46 | Tocris (Minneapolis, MN) | CAS# 1237744-13-6 | |
| software, algorithm | Perszyk2018_ sim_Markov_ Modulator Competition |
this paper | Matlab code, see sumplemental information |
|
| software, algorithm | Axopatch and Clampfit |
Molecular Devices (San Jose, CA) |
||
| software, algorithm | Easy Oocyte | Custom written Software (Emory University, Atlanta, GA) |
||
| software, algorithm | Prism | GraphPad (La Jolla, CA) | ||
| software, algorithm | Matlab | Mathworks (Natick, MA) |