Table 5. Comparison of EU1794-27, EU1794-4, and EU1794-2 effects at GluN1/GluN2C NMDAR responses to sub-saturating agonist.

GluN2C	Glu/Gly (µM)	Relative agonist Response* (% of maximal response)	Modulation by 10 µM† (% of control)
EU1794-27	100/30 1/0.3	- 20 ± 1.6	190 ± 10% 480 ± 31%‡
EU1794-4	100/30 1/0.3 0.3/0.09	- 27.7 ± 3.3 2.8 ± 0.7	54 ± 1.6% 140 ± 12%‡ 660 ± 110%‡
EU1794-2	100/30 0.6/0.2	- 21.5 ± 6.8	16 ± 1.0% 43 ± 2.1%‡

The data presented are mean ±SEM.

*Reported average responses to sub-saturating agonist were normalized to a 100/30 µM glutamate/glycine response.

^†The degree modulation is reported as a percent of the control response to sub-saturating agonist. Some of these data points correspond to those used to calculated EC₅₀ values for each modulator in Table 1, Table 2 or Supplementary file 1. Data are mean ±SEM.

^‡p<0.05 as compared to 100/30 µM glutamate/glycine response, determined by an unpaired t-test, n = 4–10 cells.