Table 7. Enantiomeric preference of EU1794-27.

	EC50 (µM) [conf. int.]* Maximal Modulation Extent (% of control)
Compound	EU1794-27	(-)-EU1794-27	(+)-EU1794-27
GluN2A	7.4 [5.3, 10]† 52 ± 7%	5.6 [2.7, 12] 67 ± 5%	-	‡
GluN2B	1.4 [1.2, 1.7]† 130 ± 3%	2.8 [2.0, 3.8] 170 ± 10%	-	‡
GluN2C	2.8 [2.5, 3.2]† 230 ± 10%	5.1 [4.1, 6.4] 260 ± 24%	7.1 [3.6, 14] 160 ± 6.2%	‡
GluN2D	2.4 [1.8, 3.3]† 250 ± 8%	8.2 [6.7, 9.9] 340 ± 21%	7.4 [3.7, 15] 130 ± 4.7%	‡

*EC₅₀ values were obtained by least-squares fitting of data from individual experiments by the Hill equation. EC₅₀ values are given as the mean with the 95% confidence interval determined from log(EC₅₀); the maximal degree of modulation is given as mean ±SEM. Data are from 4 to 7 oocytes from at least two independent experiments. Data were not fitted (shown as -) if the response recorded at 30 µM of test compound did not differ by more than 15% from control.

^†Data from Table 1 is included here for clarity.

^‡indicates significant unpaired t-test between the percent modulation between 30 µM (-)-EU1794-27 and (+)-EU1794-27.