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. Author manuscript; available in PMC: 2018 May 24.
Published in final edited form as: Nat Methods. 2018 Feb 12;15(3):213–220. doi: 10.1038/nmeth.4595

Figure 3.

Figure 3

Analysis of proteins isolated by RICK. (a) Hierarchical clustering of the ion intensities of three different LC-MS/MS experiments (n = 3 biologically independent experiments for both RICK and oligo(dT) capture (with or without EU)), colors in the heatmap indicate the pairwise Pearson correlation between the different data sets (n = 1,169). (b) Venn diagram comparing the 344 RICK-exclusive RBPs and different oligo(dT) capture studies using human cells2,18,19. The serial RNA interactome capture (serIC) study by Conrad et al.19 is a human RNA interactome using oligo(dT) capture of the nuclei of K562 cells.