Table 4.
Multivariate Cox proportional hazard regression of all-cause mortality risk for individual biological components of the allostatic load using data obtained from multiple imputation (N = 8113)
| Crude hazard ratioa | Model 1b | Model 2c | ||||||
|---|---|---|---|---|---|---|---|---|
| Variable | References | Level | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value |
| Allostatic load | Low AL (0 ≤ AL < 3) | Mid AL (3 ≤ AL < 5) | 1.98 [1.25–3.13] | 1.69E−03 | 1.81 [1.14–2.88] | 5.67E−03 | 1.71 [1.07–2.72] | 1.24E−02 |
| High AL (5 ≤ AL ≤ 12) | 3.56 [2.3–5.53] | 6.95E−09 | 2.98 [1.9–4.67] | 1.05E−06 | 2.57 [1.59–4.15] | 5.57E−05 | ||
| Neuroendocrine system | ||||||||
| Cortisol t1 | Low (0) | High (1) | 0.78 [0.48–1.27] | 8.40E−01 | 0.79 [0.48–1.28] | 8.31E−01 | 0.79 [0.49–1.29] | 8.25E−01 |
| Cortisol t1-t2 | Low (0) | High (1) | 0.91 [0.57–1.45] | 6.58E−01 | 0.9 [0.56–1.43] | 6.75E−01 | 0.94 [0.59–1.5] | 6.10E−01 |
| Immune and inflammatory system | ||||||||
| Insulin Growth Factor, IGF-1 | Low (0) | High (1) | 1.46 [1–2.13] | 2.45E−02 | 1.39 [0.95–2.03] | 4.43E−02 | 1.26 [0.86–1.86] | 1.16E−01 |
| C reactive protein, CRP | Low (0) | High (1) | 2.44 [1.73–3.45] | 2.05E−07 | 2.14 [1.51–3.04] | 1.03E−05 | 1.94 [1.34–2.81] | 2.22E−04 |
| Fibrinogen | Low (0) | High (1) | 1.95 [1.37–2.77] | 1.07E−04 | 1.69 [1.18–2.42] | 2.09E−03 | 1.49 [1.02–2.16] | 1.88E−02 |
| Immunoglobulin E, IgE | Low (0) | High (1) | 1.23 [0.84–1.8] | 1.46E−01 | 1.2 [0.81–1.76] | 1.80E−01 | 1.13 [0.77–1.66] | 2.66E−01 |
| Metabolic system | ||||||||
| High Density Lipoprotein, HDL | Low (0) | High (1) | 1.64 [1.12–2.4] | 5.85E−03 | 1.44 [0.97–2.12] | 3.38E−02 | 1.39 [0.92–2.09] | 5.71E−02 |
| Light Density Lipoprotein, LDL | Low (0) | High (1) | 0.98 [0.65–1.49] | 5.32E−01 | 0.96 [0.63-1.46] | 5.80E−01 | 0.92 [0.6-1.4] | 6.50E−01 |
| Triglycerides | Low (0) | High (1) | 1.47 [1.02–2.12] | 2.05E−02 | 1.31 [0.9–1.9] | 7.79E−02 | 1.21 [0.83–1.78] | 1.62E−01 |
| Glycated haemoglobin, Hb1A1c | Low (0) | High (1) | 1.99 [1.38–2.87] | 1.12E−04 | 1.76 [1.22–2.55] | 1.34E−03 | 1.61 [1.09–2.37] | 7.75E−03 |
| Cardiovascular system | ||||||||
| Systolic blood pressure, SBP | Low (0) | High (1) | 1.5 [1.05–2.16] | 1.40E−02 | 1.42 [0.98–2.05] | 3.05E−02 | 1.29 [0.88–1.87] | 9.41E−02 |
| Diastolic blood pressure, DBP | Low (0) | High (1) | 1.29 [0.89–1.87] | 9.32E−02 | 1.23 [0.84–1.79] | 1.40E−01 | 1.16 [0.79–1.71] | 2.19E−01 |
| Heart rate | Low (0) | High (1) | 1.99 [1.4–2.82] | 6.06E−05 | 1.91 [1.34–2.72] | 1.63E−04 | 1.68 [1.17–2.41] | 2.46E−03 |
| Peak expiratory flow | Low (0) | High (1) | 2.42 [1.71–3.41] | 2.58E−07 | 2.09 [1.47–2.97] | 2.16E−05 | 1.86 [1.3–2.67] | 3.44E−04 |
aSex-adjusted hazard ratio
bAdjusted for early life, ACEs, behaviours at 23
cModel 1 + behaviours at 42