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. 2018 May 18;9:349. doi: 10.3389/fneur.2018.00349

Table 1.

Molecular formula and chemical structure of small molecule compounds which do not directly target expanded CUG repeats and alleviate pathogenesis of myotonic dystrophy type 1.

Name Molecular formula Structure Potential mechanism of action
Pentamidine C19H24N4O2 graphic file with name fneur-09-00349-i001.jpg Inhibition of transcription
Propamidine C17H20N4O2 graphic file with name fneur-09-00349-i002.jpg
Heptamidine C21H28N4O2 graphic file with name fneur-09-00349-i003.jpg
Compound 13 C18H16N4O graphic file with name fneur-09-00349-i004.jpg
Actinomycin D C62H86N12O16 graphic file with name fneur-09-00349-i005.jpg
Phenylbuthazone C19H20N2O2 graphic file with name fneur-09-00349-i006.jpg Upregultion of muscleblind-like 1
Ketoprofen C16H14O3 graphic file with name fneur-09-00349-i007.jpg
ISOX C22H30N4O6 graphic file with name fneur-09-00349-i008.jpg
Vorinostat C14H20N2O3 graphic file with name fneur-09-00349-i009.jpg
Manumycin A C31H38N2O7 graphic file with name fneur-09-00349-i010.jpg Inhibition of H-RAS pathway
Metformin C4H11N5 graphic file with name fneur-09-00349-i011.jpg Modulation of protein kinases
AICAR C9H14N4O5 graphic file with name fneur-09-00349-i012.jpg
Ro 31-8220 C25H23N5O2S graphic file with name fneur-09-00349-i013.jpg
C16 C13H8N4OS graphic file with name fneur-09-00349-i014.jpg
C51 C23H21N5 graphic file with name fneur-09-00349-i015.jpg
Lithium chloride LiCl graphic file with name fneur-09-00349-i016.jpg
TDZD-8 C10H10N2O2S graphic file with name fneur-09-00349-i017.jpg
6-Bromoindirubin-3′-oxime C16H10BrN3O2 graphic file with name fneur-09-00349-i018.jpg
Harmine C13H12N2O graphic file with name fneur-09-00349-i019.jpg Undetermined