Table 3.
Posterior medians and 95% credible ranges for inhalation (ppm) or oral (mmol/kg) exposure and varying model parameters for the six target cmax concentrations in venous blood.
| Target Cmax (mmol/L) | Dose | BW | QPC | PS2 | kex |
|---|---|---|---|---|---|
| INHALATION DOSE (ppm) | |||||
| 0.28 | 21.59 (13.24, 31.78) | 0.249 (0.245, 0.255) | 15.53 (7.97, 22.45) | 0.808 (0.368, 1.252) | 0.0051 (0.0021, 0.0070) |
| 0.55 | 43.71 (32.46, 60.39) | 0.250 (0.246, 0.255) | 15.35 (9.16, 21.47) | 0.840 (0.345, 1.250) | 0.00051 (0.0023, 0.0071) |
| 1.11 | 81.15 (63.32, 100.95) | 0.250 (0.245, 0.255) | 16.13 (8.67, 21.89) | 0.847 (0.358, 1.281) | 0.0053 (0.0021, 0.0073) |
| 2.77 | 210.13 (165.72, 259.69) | 0.249 (0.245, 0.254) | 15.47 (8.40, 21.49) | 0.843 (0.35, 1.280) | 0.0052 (0.0021, 0.0071) |
| 5.55 | 412.60 (333.12, 521.36) | 0.251 (0.246, 0.255) | 15.61 (8.31, 22.18) | 0.901 (0.347, 1.295) | 0.0053 (0.0021, 0.0072) |
| 11.1 | 793.62 (618.11, 994.52) | 0.250 (0.245, 0.255) | 15.95 (9.45, 21.31) | 0.893 (0.360, 1.311) | 0.0050 (0.0022, 0.0070) |
| ORAL DOSE (mmol kg−1 bw) | |||||
| 0.28 | 0.267 (0.143, 0.326) | 0.249 (0.245, 0.254) | 1.02 (0.446, 1.288) | 0.0046 (0.0019, 0.0070) | |
| 0.55 | 0.510 (0.268, 0.639) | 0.249 (0.245, 0.254) | 0.961 (0.404, 1.305) | 0.0045 (0.0019, 0.0072) | |
| 1.11 | 0.920 (0.483, 1.210) | 0.249 (0.245, 0.255) | 0.941 (0.398, 1.262) | 0.0047 (0.0018, 0.0071) | |
| 2.77 | 2.454 (1.264, 3.108) | 0.249 (0.245, 0.254) | 0.991 (0.409, 1.290) | 0.0047 (0.0022, 0.0069) | |
| 5.55 | 4.586 (2.297, 5.860) | 0.250 (0.245, 0.255) | 0.929 (0.381, 1.208) | 0.0047 (0.0020, 0.007) | |
| 11.1 | 9.151 (5.100, 11.759) | 0.250 (0.245, 0.254) | 0.908 (0.421, 1.191) | 0.0047 (0.0022, 0.0071) | |