Table 5.

Comparison of predicted and measured benchmark doses for oral and inhalation exposure.

Exposure route	Days of exposure	Dose (mmol kg−1 bw)	Critical end point	Measured BMDL10	Predicted BMDL10
					Mean	2.5%	97.5%	Lab 1	Lab 2
Oral	GD7-13	0.3, 0.6, 1.1	Cardiac malformationsa	0.46	0.32	0.29	0.36	0.12c	0.34c
			Resorptionsa	0.52
			Fetal bw decreasea	0.14
		Dose (ppm)
Inhalation	GD7-15 (7 h/day)	50, 100, 200	Skeletal malformationsb	11	34	28	42	21	64
			Visceral malformationsb	41
			Resorptionsb	49
			Fetal bw decreaseb	37

^aToraason et al. (1985).

^bNelson et al. (1984).

^cLouisse et al. (2010).