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. 2018 May 18;11:162. doi: 10.3389/fnmol.2018.00162

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Copyright © 2018 Li, Wang, Ma, Wang, Niu, Li and Xiao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Oligodendroglial cells selectively express ryanodine receptor 3 (RyR3), which is downregulated during differentiation. (A) Immunofluorescence staining of RyR3, Olig2 (oligodendroglial lineage marker) and myelin basic protein (MBP; mature OL marker) in three stages of cultured OL lineage cells. RyR3 was strongly distributed all over the cytoplasm and processes in oligodendrocyte progenitor cells (OPCs) and immature oligodendrocytes (imOLs), while in mature OLs, RyR3 signal was mainly located in the cell body and showed lower expression in the primary processes. Scale bar 20 μm. (B) mRNA levels of RyRs in OL lineage cells, astrocytes (AST) and rat brain tissue. (C,D) Western blot analysis showed increased levels of myelin proteins (CNPase, MBP) and decreased levels of RyR3 protein during OPC development (*p < 0.05, **p < 0.01).