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. 2018 May 18;11:162. doi: 10.3389/fnmol.2018.00162

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Copyright © 2018 Li, Wang, Ma, Wang, Niu, Li and Xiao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Knockdown of RyR3 in OPCs results in inhibition of OPC differentiation. (A,B) Gene knockdown of RyR3 with shRNA interference mediated by lentivirus infection showed fewer MBP-positive mature OLs after 48 h of differentiation. GFP was expressed in lentivirus-infected cells (**p < 0.05). Scale bar 20 μm. (C,D) Knockdown of RyR3 in OPCs by antisense oligonucleotide (+aODN) resulted in less expression of myelin basic protein (MBP; **p < 0.05).