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. 2018 May 18;11:162. doi: 10.3389/fnmol.2018.00162

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Copyright © 2018 Li, Wang, Ma, Wang, Niu, Li and Xiao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Scheme illustrating the contribution of RyR3-mediated Ca²⁺ signaling during oligodendroglial development. RyR3, a Ca²⁺-induced Ca²⁺ release (CICR) channel located on the ER membrane during oligodendroglial differentiation, note that it is widely distributed in the cell body and processes of OPC/imOLs but down-regulated and restricted in the cell body of mature OLs. The initiation of OPC differentiation requires hyperactive Ca²⁺ signaling mediated by RyR3. RyR3 knockdown or blockage of RyR3-mediated Ca²⁺ signaling in OPCs results in inhibition of OPC differentiation.