Figure 1.

Experimental outline and diverse assessments of the implanted hippocampal electrodes. (A) Schematic diagram of the experiments. See text for details. (B) Representative hippocampal EEG traces collected from a mouse during baseline monitoring and following extended hippocampal kindling. Arrows show interictal spikes. (C) Frequencies of theta rhythms and irregular activities from mice in the control and the extended hippocampal kindled groups. (D) Verification of deep electrode site. Image obtained from a mouse following extended hippocampal kindling. Track denoted by a filled arrow. (E) Schematic illustrations correspond to coronal brain sections between 2.6 and 2.9 mm posterior to bregma. The solid squares indicate the correct localization of the electrode tips (blue represents 4 control animals and red represents 5 extended hippocampal kindled animals).