Table 1.
Mouse number/total stimuli applied to achieve extended kindling | SRS events/monitoring times | AEDs tested in each mouse | |
---|---|---|---|
Initial# (h) | Later$ (h) | ||
#1, 120 | 7/48 | 4/24 | PHE25mg/kg |
#2, 140 | 13/72 | 16/144 | PHE25mg/kg |
#3, 140 | 22/48 | 12/48 | PHE25mg/kg, LEV100mg/kg |
#4, 100 | 9/48 | 17/72 | PHE25mg/kg, LEV100mg/kg |
#5, 100 | 10/48 | 5/40 | PHE25mg/kg, LEV100mg/kg |
#6, 100 | 11/66 | 6/24 | PHE25mg/kg, LEV100mg/kg |
#7, 140 | 23/72 | 26/93 | LOZ1.5mg/kg, LEV100, 400mg/kg |
#8, 120 | 20/72 | 20/72 | LOZ1.5mg/kg, LEV100, 400mg/kg |
#9, 120 | 17/72 | 10/24 | LOZ1.5mg/kg, LEV400mg |
#10, 120 | 9/48 | 17/72 | LOZ1.5mg/kg, LEV400mg |
#11, 120 | 7/48 | 4/24 | LOZ1.5mg/kg, LEV400mg |
#12, 120 | 13/72 | 16/144 | LOZ1.5mg/kg, LEV400mg |
Mouse Number/totalandlings Applied | |||
#1-#8, 120 | 0/48 h |
PHE, phenytoin; LOZ, lorazepam; LEV, levetiracetam;
individual mice were monitored initially within 3 days after termination of kindling stimulation; then, monitored 8–11 weeks later. Control mice were monitored after 120 handling manipulations.